Term Name: methylthioadenosine-DADMe immucillin-A
Synonyms: (3R,4S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-ylmethyl)-4-methylsulfanylmethyl-pyrrolidin-3-ol, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-3-pyrrolidinol, methylthio-DADMe-immucillin A, methylthio-DADMe-immucillin-A, MT-DADMe-ImmA, MT-DADMe-Immucillin-A, MTDIA
Definition: A pyrrolopyrimidine that is 5H-pyrrolo[3,2-d]pyrimidin-4-amine substituted by a {(3R,4S)-3-hydroxy-4-[(methylsulfanyl)methyl]pyrrolidin-1-yl}methyl group at position 7. It is a potent inhibitor of human 5'-methylthioadenosine phosphorylase (Ki = 86 pM) with anti-tumour activity.
Ontology: ChEBI [CHEBI:234322]  ( EBI )

Relationships
is a type of: aromatic amine methyl sulfide monohydroxypyrrolidine pyrrolopyrimidine secondary alcohol tertiary amino compound
has_role: antineoplastic agent apoptosis inducer EC 2.4.2.28 (S-methyl-5'-thioadenosine phosphorylase) inhibitor