Term Name:	cofactor
Synonyms:	cofactor, cofactors
Definition:	An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
Ontology:	ChEBI [CHEBI:23357] ( EBI )

Relationships

is a type of:	biochemical role
has subtype:	coenzyme prosthetic group siderophore
inverse has_role:	(6R)-5,10-methylenetetrahydrofolate(2-) (6R)-5,10-methylenetetrahydrofolic acid (6S)-5,6,7,8-tetrahydrofolate(2-) (6S)-5,6,7,8-tetrahydrofolic acid (R)-lipoate (R)-lipoic acid 1,4-benzoquinone 3'-hydroxyechinenone 5,6,7,8-tetrahydropteridine 5-hydroxybenzimidazolylcob(I)amide 5-hydroxybenzimidazolylcob(I)amide(1-) 6,7-dimethyl-8-(1-D-ribityl)lumazine 6,7-dimethyl-8-(1-D-ribityl)lumazine(1-) 6-decylubiquinone 6-hydroxy-FAD 6-hydroxy-FAD(3-) adenosine 5'-monophosphate adenosine 5'-monophosphate(2-) ammonium ATP ATP(3-) ATP(4-) bacillithiol barium(2+) beta-carotene biotin biotinate bis(molybdopterin)tungsten cofactor cadmium(2+) calcium(2+) cerium(3+) chloride chlorophyll a chlorophyll a(1-) chlorophyll b chlorophyll b(1-) cob(I)alamin cob(I)alamin(1-) cob(II)alamin cobalamin cobalt(2+) cobalt(3+) cobamamide coenzyme F430 coenzyme F430(4-) copper cation copper(1+) copper(2+) corrin corrinoid decylplastoquinone dehydro-D-arabinono-1,4-lactone dihydrogenvanadate dihydrolipoamide dipyrromethane cofactor dipyrromethane cofactor(4-) divinyl chlorophyll a divinyl chlorophyll a(1-) divinyl chlorophyll b divinyl chlorophyll b(1-) echinenone FAD FAD(3-) Fe-coproporphyrin III Fe-coproporphyrin III(4-) Fe4S2O2 iron-sulfur-oxygen cluster ferriheme a ferriheme a(1-) ferroheme b ferroheme b(2-) ferroheme c ferroheme c(2-) flavin adenine dinucleotide flavin mononucleotide FMN FMN(3-) FMNH2 FMNH2(2-) glutathionate(1-) glutathione heme d cis-diol heme d cis-diol(2-) heme o hydrogen peroxide hydrogencarbonate hydrogenphosphate hydroquinone iron cation iron(2+) iron(3+) iron-sulfur-iron cofactor iron-sulfur-molybdenum cofactor iron-sulfur-vanadium cofactor L-ascorbate L-ascorbic acid lanthanum cation lanthanum(3+) lead(2+) magnesium(2+) manganese(2+) menaquinone-7 methylcobalamin molybdopterin cofactor mycothiol myo-inositol hexakisphosphate myo-inositol hexakisphosphate(12-) NAD(+) NAD(1-) NADH NADH(2-) NADP(+) NADP(3-) NADPH NADPH(4-) Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide(1-) Ni(II)-pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel cation nickel(2+) nicotinamide NiFe4S4 cluster NiFe4S5 cluster pantetheine 4'-phosphate pantetheine 4'-phosphate(2-) pantothenic acids phylloquinone phytochromobilin polypeptide-derived cofactor porphyrins potassium(1+) premycofactocin prenyl-FMN prenyl-FMN(2-) prenyl-FMNH2 pyridoxal pyridoxal 5'-phosphate pyridoxal 5'-phosphate(2-) pyridoxal hydrochloride pyridoxine pyrroloquinoline cofactor pyrroloquinoline quinone pyrroloquinoline quinone(3-) pyruvate pyruvic acid riboflavin riboflavin(1-) S-adenosyl-L-homocysteine S-adenosyl-L-methionine S-adenosyl-L-methionine zwitterion sapropterin siroheme siroheme(8-) sirohydrochlorin sirohydrochlorin(8-) sodium(1+) strontium(2+) sulfate tetra-mu3-sulfido-tetrairon tetrahydromonapterin thiamine(1+) diphosphate thiamine(1+) diphosphate(3-) vanadium cation vitamin B6 phosphate zeaxanthin zinc(2+)