Term Name: JHU083
Synonyms: ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate, ethyl (2S)-2-{[(2S)-2-amino-4-methylpentanoyl]amino}-6-diazo-5-oxohexanoate, ethyl (S)-2-((S)-2-amino-4-methylpentanamido)-6-diazo-5-oxohexanoate, ethyl L-leucyl-6-diazo-5-oxo-L-norleucinate, JHU 083, JHU-083
Definition: An ethyl ester resulting from the formal condensation of the carboxy group of L-leucyl-6-diazo-5-oxo-L-norleucine with ethanol. It is a glutaminase inhibitor and a prodrug of 6-diazo-5-oxo-L-norleucine that exhibits antineoplastic activity.
Ontology: ChEBI [CHEBI:232049]  ( EBI )

Relationships
is a type of: diazo compound ethyl ester ketone L-leucine derivative secondary carboxamide
has_role: antineoplastic agent EC 3.5.1.2 (glutaminase) inhibitor prodrug