Term Name: | CT3 |
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Synonyms: | 1-(2-{5-[5-fluoro-2-(trifluoromethyl)pyridin-3-yl]-1,3-dihydro-2H-isoindol-2-yl}-2-oxoethyl)-1H-1,2,4-triazole-3-carbonitrile, 1-(2-{5-[5-fluoro-2-(trifluoromethyl)pyridin-3-yl]isoindolin-2-yl}-2-oxoethyl)-1H-1,2,4-triazole-3-carbonitrile, 1-[2-[5-[5-fluoro-2-(trifluoromethyl)-3-pyridinyl]-1,3-dihydro-2H-isoindol-2-yl]-2-oxoethyl]-1H-1,2,4-triazole-3-carbonitrile, compound CT3, CT 3, CT-3, cyanotriazole 3, topoisomerase II inhibitor 16 |
Definition: | A member of the class of isoindoles that is 2,3-dihydro-1H-isoindole substituted by (3-cyano-1H-1,2,4-triazol-1-yl)acetyl and 5-fluoro-2-(trifluoromethyl)pyridin-3-yl groups at positions 2 and 5, respectively. It inhibits Trypanosoma cruzi topoisomerase II and eradicates Trypanosoma cruzi in a mouse model of Chagas disease. |
Ontology: | ChEBI [CHEBI:231816] ( EBI ) |