Term Name: | ITK7 |
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Synonyms: | 8-methyl-7-(prop-1-yn-1-yl)-2-((pyrimidin-2-ylthio)methyl)quinazolin-4(3H)-one, 8-methyl-7-(prop-1-yn-1-yl)-2-[(pyrimidin-2-ylsulfanyl)methyl]quinazolin-4(3H)-one, 8-methyl-7-prop-1-ynyl-2-(pyrimidin-2-ylsulfanylmethyl)-3H-quinazolin-4-one, ITK 7, ITK-7, PARP11 inhibitor ITK7 |
Definition: | A member of the class of quinazolines that is quinazolin-4(3H)-one substituted by (pyrimidin-2-ylsulfanyl)methyl, prop-1-yn-1-yl, and methyl groups at positions 2, 7, and 8, respectively. It is a potent PARP11 inhibitor (IC50 = 14 nM). |
Ontology: | ChEBI [CHEBI:231599] ( EBI ) |