Term Name: orteronel
Synonyms: (+)-orteronel, (S)-orteronel, 6-[(7S)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide, orteronel, orteronelum, TAK 700, TAK-700, TAK700
Definition: A member of the class of pyrroloimidazoles that is 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole substituted by hydroxy and 6-(methylcarbamoyl)naphthalen-2-yl groups at position 7 (the 7S-stereoisomer). It is a non-steroidal 17,20-lyase inhibitor that suppresses androgen synthesis. It was previously in clinical development for the treatment of castration-resistant prostate cancer -- trial now discontinued.
Ontology: ChEBI [CHEBI:231353]  ( EBI )

Relationships
is a type of: naphthalenecarboxamide pyrroloimidazole secondary carboxamide tertiary alcohol
has_role: antineoplastic agent EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor sterol biosynthesis inhibitor