Term Name: | 6-O-methylguanine |
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Synonyms: | 2-Amino-6-methoxypurine, 6-Methoxy-1H-purine-2-amine, 6-methoxy-7H-purin-2-amine, 6-Methoxyguanine, O(6)-methylguanine, O-(6)-Methylguanine |
Definition: | A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA. |
Ontology: | ChEBI [CHEBI:20689] ( EBI ) |