Term Name: beauveriolide I
Synonyms: (3R,6S,9S,13S)-9-benzyl-13-[(2S)-hexan-2-yl]-6-methyl-3-(2-methylpropyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
Definition: A cyclodepsipeptide with formula C27H41N3O5. It was originally isolated from the fungus Beauveria sp. FO-6979 during a screening program for inhibitors of lipid droplet accumulation in murine macrophages. It is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT) and effective at reducing atherogenic lesions of the artery and heart in mouse models.
Ontology: ChEBI [CHEBI:180490]  ( EBI )

Relationships
is a type of: cyclodepsipeptide macrocycle
has_role: antiatherogenic agent antiatherosclerotic agent EC 2.3.1.26 (sterol O-acyltransferase) inhibitor fungal metabolite geroprotector