Term Name: rigosertib
Synonyms: (E)-ON 01910, [2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)anilino]acetic acid, N-[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine, ON 01910, ON-01910, rigosertib, rigosertibum
Definition: An N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine in which the double bond has E-configuration. It is a non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM and exhibits anti-cancer properties.
Ontology: ChEBI [CHEBI:145417]  ( EBI )

Relationships
is a type of: N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine
has_role: antineoplastic agent apoptosis inducer EC 2.7.11.21 (polo kinase) inhibitor microtubule-destabilising agent
inverse is_conjugate_base_of: rigosertib(1-)
is_conjugate_acid_of: rigosertib(1-)