Term Name: rubimaillin
Synonyms: methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate, mollugin
Definition: A benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-α-induced NF-κB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme.
Ontology: ChEBI [CHEBI:141063]  ( EBI )

Relationships
is a type of: benzochromene methyl ester phenols
has_role: acyl-CoA:cholesterol acyltransferase 2 inhibitor anti-inflammatory agent antineoplastic agent apoptosis inducer neuroprotective agent NF-kappaB inhibitor plant metabolite