Term Name: | rubimaillin |
---|---|
Synonyms: | methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate, mollugin |
Definition: | A benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. |
Ontology: | ChEBI [CHEBI:141063] ( EBI ) |