Term Name: 6beta-hydroxycortisol
Synonyms: (6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione, 6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione, 6beta,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione, 6beta-HO-cortisol, 6beta-hydroxycortisol, 6beta-OH-cortisol, NSC 76163
Definition: A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
Ontology: ChEBI [CHEBI:139271]  ( EBI )

Relationships
is a type of: 3-oxo-Delta(4) steroid 6beta-hydroxy steroid 11beta-hydroxy steroid 17alpha-hydroxy steroid 20-oxo steroid 21-hydroxy steroid C21-steroid primary alpha-hydroxy ketone tertiary alpha-hydroxy ketone
has_functional_parent: cortisol
has_role: human metabolite mammalian metabolite probe