Term Name: | 6beta-hydroxycortisol |
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Synonyms: | (6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione, 6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione, 6beta,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione, 6beta-HO-cortisol, 6beta-hydroxycortisol, 6beta-OH-cortisol, NSC 76163 |
Definition: | A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. |
Ontology: | ChEBI [CHEBI:139271] ( EBI ) |