Term Name: | 6beta-hydroxycortisone |
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Synonyms: | 6beta,17,21-trihydroxypregn-4-ene-3,11,20-trione, 6beta-17alpha,21-trihydroxypregn-4-ene-3,11,20-trione, 6beta-hydroxycortisone |
Definition: | A C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6beta-position. It is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo. |
Ontology: | ChEBI [CHEBI:139269] ( EBI ) |