Term Name: 6-diazo-5-oxo-L-norleucine
Synonyms: (S)-2-amino-6-diazo-5-oxocaproic acid, 6-diazo-5-oxo-L-norleucine, diazooxonorleucine, L-DON
Definition: A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes.
Ontology: ChEBI [CHEBI:138889]  ( EBI )

Relationships
is a type of: diazo compound ketone non-proteinogenic L-alpha-amino acid
has_role: analgesic antibacterial agent antimetabolite antineoplastic agent antiviral agent apoptosis inducer bacterial metabolite EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor EC 3.5.1.2 (glutaminase) inhibitor EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor glutamine antagonist
inverse is_tautomer_of: 6-diazo-5-oxo-L-norleucine zwitterion
is_tautomer_of: 6-diazo-5-oxo-L-norleucine zwitterion