Term: epidermal basal stratum canonical Wnt signaling pathway
Note: This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name.
Name: epidermal basal stratum
Synonyms: basal epidermal layer
Definition: Lower layer of the epidermis. Composed of a single layer of cells. The major function of the basal stratum is to keep the epidermis attached to the underlying dermis by means of (hemidesmosomes attached to the basement membrane.
Ontology: Anatomy Ontology [ZFA:0001180]
Name: canonical Wnt signaling pathway
Synonyms: canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway, Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin
Definition: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Ontology: GO: Biological Process [GO:0060070]   QuickGO   AmiGO