Term: integument I-kappaB kinase/NF-kappaB signaling
Note: This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name.
Name: integument
Synonyms: skin
Definition: The outer protective barrier that separates the animal from its aquatic environment.
Ontology: Anatomy Ontology [ZFA:0000368]
Name: I-kappaB kinase/NF-kappaB signaling
Synonyms: activation of the inhibitor of kappa kinase, canonical NF-kappaB signaling cascade, I-kappaB kinase/NF-kappaB cascade, I-kappaB kinase/NF-kappaB signal transduction, NF-kappaB cascade, p50-dependent NF-kappaB signaling
Definition: The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Ontology: GO: Biological Process [GO:0007249]   QuickGO   AmiGO