| Name: | keratinocyte |
|---|---|
| Synonyms: | keratinocytes |
| Definition: | An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. |
| Ontology: | Anatomy Ontology [ZFA:0009158] |
| Name: | DNA damage response |
|---|---|
| Synonyms: | cellular DNA damage response, cellular response to DNA damage stimulus, response to DNA damage stimulus, response to genotoxic stress |
| Definition: | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| Ontology: | GO: Biological Process [GO:0006974] QuickGO AmiGO |