Gene
acvr1l
- ID
- ZDB-GENE-990415-9
- Name
- activin A receptor, type 1 like
- Symbol
- acvr1l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and transforming growth factor beta receptor activity, type I. Involved in several processes, including animal organ development; embryonic morphogenesis; and regulation of transcription by RNA polymerase II. Localizes to BMP receptor complex and cell cortex. Human ortholog(s) of this gene implicated in fibrodysplasia ossificans progressiva. Is expressed in brain; ceratobranchial 5 tooth; immature eye; liver; and tooth placode. Orthologous to human ACVR1 (activin A receptor type 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151393 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 18 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003605 | GS domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Length | Activin types I and II receptor domain | GS domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:O73736
|
506 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
acvr1l-201
(1)
|
Havana | 3499 nt | |
| mRNA |
acvr1l-202
(1)
|
Havana | 457 nt | |
| ncRNA |
acvr1l-002
(1)
|
Havana | 396 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB1-acvr1l | polyclonal | Rabbit |
|
2 |
Plasmids