ZFIN ID: ZDB-GENE-990415-273
Gene Name: vascular endothelial growth factor Aa
Gene Symbol: vegfaa
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function chemoattractant activity IBA RGD:619991, UniProtKB:P49767, UniProtKB:P49765, UniProtKB:P15692, UniProtKB:O43915, PANTHER:PTN000246442, MGI:MGI:103178 Gaudet et al., 2010
growth factor activity IBA UniProtKB:P49763, RGD:619991, MGI:MGI:108037, UniProtKB:P15692, PANTHER:PTN000246442, UniProtKB:P15691, MGI:MGI:103178 Gaudet et al., 2010
growth factor activity IEA InterPro:IPR000072 ZFIN Electronic Annotation
growth factor activity IEA UniProtKB-KW:KW-0339 ZFIN Electronic Annotation
growth factor activity IMP Liang et al., 2001
heparin binding IEA InterPro:IPR027928 ZFIN Electronic Annotation
heparin binding IEA InterPro:IPR036841 ZFIN Electronic Annotation
protein binding IPI nrp1b Bovenkamp et al., 2004
vascular endothelial growth factor receptor 1 binding IBA UniProtKB:P49765, PANTHER:PTN002635039, UniProtKB:P15692, MGI:MGI:103178 Gaudet et al., 2010
vascular endothelial growth factor receptor binding IBA MGI:MGI:108037, RGD:619991, UniProtKB:P49767, UniProtKB:P49765, UniProtKB:P15692, RGD:619800, UniProtKB:O43915, PANTHER:PTN000246442, MGI:MGI:103178, MGI:MGI:109124 Gaudet et al., 2010
Cellular Component extracellular region IEA UniProtKB-KW:KW-0964 ZFIN Electronic Annotation
extracellular space IBA MGI:MGI:108037, RGD:619991, UniProtKB:P49765, UniProtKB:P15692, UniProtKB:P15691, PANTHER:PTN000246442, MGI:MGI:103178, MGI:MGI:105095, MGI:MGI:109124, RGD:619850 Gaudet et al., 2010
membrane IEA InterPro:IPR000072 ZFIN Electronic Annotation
Biological Process activation of phospholipase C activity IDA Leung et al., 2006
angioblast cell migration from lateral mesoderm to midline IMP MO1-vegfaa Childs et al., 2002
angiogenesis IBA RGD:619991, RGD:619800, UniProtKB:P15692, RGD:619799, PANTHER:PTN000246442, MGI:MGI:103178, RGD:619850 Gaudet et al., 2010
angiogenesis IDA Liang et al., 2001
angiogenesis IEA UniProtKB-KW:KW-0037 ZFIN Electronic Annotation
angiogenesis IGI flt1 Wild et al., 2017
angiogenesis IGI MO2-vegfc, MO1-vegfaa, MO1-vegfc Covassin et al., 2006
angiogenesis IGI MO1-tek, MO1-vegfaa Li et al., 2014
angiogenesis IMP 2 Publications
angiogenesis IMP MO1-vegfaa 4 Publications
angiogenesis IMP MO2-vegfaa Christie et al., 2010
angiogenesis IMP vegfaabns1/bns1 Rossi et al., 2016
artery morphogenesis IMP MO3-vegfaa Herbert et al., 2009
blood vessel development IMP MO1-vegfaa Jensen et al., 2015
blood vessel development IMP MO2-vegfaa 2 Publications
blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA Leung et al., 2006
branching involved in blood vessel morphogenesis IGI MO1-igfbp7, MO1-vegfaa Hooper et al., 2009
branching involved in blood vessel morphogenesis IMP Nasevicius et al., 2000
branching involved in blood vessel morphogenesis IMP MO1-vegfaa Hooper et al., 2009
cardioblast migration to the midline involved in heart rudiment formation IMP vegfaazf1090/zf1090 Zhu et al., 2017
cell differentiation IEA UniProtKB-KW:KW-0221 ZFIN Electronic Annotation
endocardial progenitor cell migration to the midline involved in heart field formation IGI MO1-robo1, MO2-slit2, MO1-mir218, MO3-vegfaa Fish et al., 2011
hemopoiesis IDA Liang et al., 2001
hemopoiesis IMP Liang et al., 2001
induction of positive chemotaxis IBA UniProtKB:P49767, UniProtKB:P49765, UniProtKB:O43915, UniProtKB:P15692, PANTHER:PTN000246442 Gaudet et al., 2010
motor neuron axon guidance IGI MO2-nrp1a, MO1-vegfaa Feldner et al., 2005
multicellular organism development IEA UniProtKB-KW:KW-0217 ZFIN Electronic Annotation
positive regulation of angiogenesis IBA RGD:619991, UniProtKB:P49765, UniProtKB:P15692, PANTHER:PTN000246442, MGI:MGI:103178, RGD:619850, MGI:MGI:109124 Gaudet et al., 2010
positive regulation of angiogenesis IMP MO1-vegfaa Stahlhut et al., 2012
positive regulation of cell division IEA UniProtKB-KW:KW-0497 ZFIN Electronic Annotation
positive regulation of endothelial cell proliferation IBA UniProtKB:P49765, UniProtKB:P15692, PANTHER:PTN000246442, UniProtKB:P15691, MGI:MGI:103178, RGD:619850 Gaudet et al., 2010
positive regulation of endothelial cell proliferation ISS UniProtKB:P15692 GOA et al., 2007
positive regulation of focal adhesion assembly ISS UniProtKB:P15692 GOA et al., 2007
positive regulation of mast cell chemotaxis IBA UniProtKB:P49767, UniProtKB:P49765, UniProtKB:P15692, UniProtKB:O43915, PANTHER:PTN000246442 Gaudet et al., 2010
positive regulation of peptidyl-tyrosine phosphorylation ISS UniProtKB:P15692 GOA et al., 2007
positive regulation of protein phosphorylation IBA UniProtKB:P49765, UniProtKB:P15692, RGD:619800, PANTHER:PTN000246442, MGI:MGI:103178, MGI:MGI:109124 Gaudet et al., 2010
positive regulation of protein-containing complex assembly ISS UniProtKB:P15692 GOA et al., 2007
pronephros development IMP MO1-vegfaa Liu et al., 2006
protein kinase B signaling IDA Leung et al., 2006
regulation of angioblast cell migration involved in selective angioblast sprouting IMP MO3-vegfaa Herbert et al., 2009
regulation of heart contraction IMP MO1-vegfaa Rottbauer et al., 2005
regulation of vasculature development IGI MO1-arntl1a, MO1-vegfaa Jensen et al., 2012
response to glucose IDA Jung et al., 2016
response to hypoxia IBA RGD:619991, UniProtKB:P15692, UniProtKB:P15691, PANTHER:PTN000246442, RGD:619850 Gaudet et al., 2010
sprouting angiogenesis IBA UniProtKB:P15692, PANTHER:PTN000246442, MGI:MGI:103178, RGD:619850 Gaudet et al., 2010
sprouting angiogenesis IGI MO1-gng2 Leung et al., 2006
sprouting angiogenesis IGI MO1-gng2, MO1-vegfaa Leung et al., 2006
sprouting angiogenesis IGI MO1-igfbp7, MO1-vegfaa Hooper et al., 2009
sprouting angiogenesis IGI MO1-e2f7, MO1-vegfaa, MO1-e2f8 Weijts et al., 2012
sprouting angiogenesis IMP MO1-vegfaa 2 Publications
sprouting angiogenesis IMP MO3-vegfaa Herbert et al., 2009
thyroid gland development IMP MO2-vegfaa Alt et al., 2006
vascular endothelial growth factor receptor signaling pathway IBA RGD:619991, MGI:MGI:108037, UniProtKB:P49767, UniProtKB:P15692, PANTHER:PTN000246442, MGI:MGI:103178, MGI:MGI:109124 Gaudet et al., 2010
vascular endothelial growth factor receptor signaling pathway IGI gli2aty119/ty119 Lawson et al., 2002
vascular endothelial growth factor signaling pathway IBA UniProtKB:P15692, PANTHER:PTN000246442, MGI:MGI:103178 Gaudet et al., 2010
vasculature development IGI MO2-nrp1a, MO1-vegfaa Lee et al., 2002
vasculature development IMP MO1-vegfaa 2 Publications
vasculature development IMP MO2-vegfaa Jia et al., 2013
vasculogenesis IDA Liang et al., 2001
vasculogenesis IMP 2 Publications
vasculogenesis IMP MO1-vegfaa 2 Publications