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General Information
ZIRC
ZFIN ID: ZDB-GENE-061013-24
Gene Name: mitochondrial calcium uniporter
Gene Symbol: mcu
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function calcium channel activity IBA UniProtKB:Q8NE86, PANTHER:PTN000335994 Gaudet et al., 2010
calcium channel activity IEA UniProtKB-KW:KW-0107 ZFIN Electronic Annotation
calcium channel activity ISS UniProtKB:Q8NE86 GOA et al., 2007
identical protein binding IPI UniProtKB:Q08BI9 Baradaran et al., 2018
uniporter activity IBA RGD:1589771, UniProtKB:Q8NE86, PANTHER:PTN000335993 Gaudet et al., 2010
uniporter activity ISS UniProtKB:Q8NE86 GOA et al., 2007
Cellular Component integral component of membrane IEA UniProtKB-KW:KW-0812 ZFIN Electronic Annotation
integral component of mitochondrial inner membrane IBA UniProtKB:Q9NWR8, UniProtKB:Q8NE86, PANTHER:PTN000335994 Gaudet et al., 2010
integral component of mitochondrial inner membrane ISS UniProtKB:Q8NE86 GOA et al., 2007
membrane IEA UniProtKB-KW:KW-0472 ZFIN Electronic Annotation
mitochondrial inner membrane IEA UniProtKB-KW:KW-0999 ZFIN Electronic Annotation
mitochondrion IEA UniProtKB-KW:KW-0496 ZFIN Electronic Annotation
uniplex complex IBA UniProtKB:Q9NWR8, UniProtKB:Q8NE86, PANTHER:PTN000335994 Gaudet et al., 2010
uniplex complex ISS UniProtKB:Q8NE86 GOA et al., 2007
Biological Process actin filament organization IMP MO1-mcu Prudent et al., 2013
calcium import into the mitochondrion IBA FB:FBgn0042185, UniProtKB:Q8NE86, dictyBase:DDB_G0286429, WB:WBGene00019296, PANTHER:PTN000335994 Gaudet et al., 2010
calcium import into the mitochondrion IDA Baradaran et al., 2018
calcium import into the mitochondrion ISS UniProtKB:Q8NE86 GOA et al., 2007
calcium ion transmembrane transport IEA UniProtKB-KW:KW-0107 ZFIN Electronic Annotation
calcium ion transport IEA UniProtKB-KW:KW-0109 ZFIN Electronic Annotation
calcium-mediated signaling ISS UniProtKB:Q8NE86 GOA et al., 2007
chordate embryonic development IMP MO1-mcu Prudent et al., 2013
convergent extension involved in gastrulation IMP MO1-mcu Prudent et al., 2013
glucose homeostasis ISS UniProtKB:Q8NE86 GOA et al., 2007
ion transport IEA UniProtKB-KW:KW-0406 ZFIN Electronic Annotation
mitochondrial calcium ion homeostasis IBA MGI:MGI:1914065, RGD:1589771, FB:FBgn0042185, WB:WBGene00019296, PANTHER:PTN000335994 Gaudet et al., 2010
mitochondrial calcium ion homeostasis IEA InterPro:IPR039055 ZFIN Electronic Annotation
positive regulation of insulin secretion ISS UniProtKB:Q8NE86 GOA et al., 2007
positive regulation of mitochondrial calcium ion concentration ISS UniProtKB:Q8NE86 GOA et al., 2007
protein complex oligomerization ISS UniProtKB:Q8NE86 GOA et al., 2007
regulation of heart contraction IGI MO2-mcu, slc8a1atc318d/tc318d Shimizu et al., 2015