Gene
il10
- ID
- ZDB-GENE-051111-1
- Name
- interleukin 10
- Symbol
- il10 Nomenclature History
- Previous Names
-
- zgc:194510
- zgc:194518
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity. Involved in defense response to bacterium and response to lipopolysaccharide. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is expressed in blood; digestive system; gill; and pleuroperitoneal region. Orthologous to human IL10 (interleukin 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 65 figures from 49 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| graft-versus-host disease | Alliance | {Graft-versus-host disease, protection against} | 614395 |
| rheumatoid arthritis | Alliance | {Rheumatoid arthritis, progression of} | 180300 |
| {HIV-1, susceptibility to} | 609423 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Four-helical cytokine-like, core | Interleukin-10 | Interleukin-10/19/20/22/24/26 family |
|---|---|---|---|---|
|
UniProtKB:Q5EFQ8
|
180 |
Interactions and Pathways
Plasmids
No data available