Gene

tdp2b

ID

ZDB-GENE-050816-1

Name

tyrosyl-DNA phosphodiesterase 2b

Symbol

tdp2b Nomenclature History

Previous Names

tdp2
ttrap
ttrapl

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Exhibits DNA binding activity and tyrosyl-DNA phosphodiesterase activity. Involved in convergent extension involved in gastrulation; determination of left/right symmetry; and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to localize to PML body and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 23. Is expressed in Kupffer's vesicle; forerunner cell group; and tail bud. Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7157406 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Esguerra et al., 2007
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tdp2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 23	Alliance	Spinocerebellar ataxia, autosomal recessive 23	616949

Associated With tdp2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005135	Endonuclease/exonuclease/phosphatase
Homologous_superfamily	IPR009060	UBA-like superfamily
Homologous_superfamily	IPR036691	Endonuclease/exonuclease/phosphatase superfamily