Gene
prkcaa
- ID
- ZDB-GENE-050208-100
- Name
- protein kinase C, alpha, a
- Symbol
- prkcaa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in blood coagulation. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; large cell carcinoma; malignant glioma (multiple); and reproductive organ cancer (multiple). Is expressed in EVL; hatching gland; nervous system; neural tube; and trigeminal placode. Orthologous to human PRKCA (protein kinase C alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139045 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Williams et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pituitary tumor, invasive |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Domain | IPR034663 | Classical Protein Kinase C alpha, catalytic domain |
| Family | IPR014375 | Protein kinase C, alpha/beta/gamma types |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | C1-like domain superfamily | C2 domain | C2 domain superfamily | Classical Protein Kinase C alpha, catalytic domain | Diacylglycerol/phorbol-ester binding | Protein kinase, ATP binding site | Protein kinase C, alpha/beta/gamma types | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QIY5
|
670 | |||||||||||||
|
UniProtKB:A0A8M9PM31
|
679 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-prkca | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
6 | |
| Ab1-prkca | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
24 |
Plasmids
No data available