Gene

notch3

ID

ZDB-GENE-000329-5

Name

notch receptor 3

Symbol

notch3 Nomenclature History

Previous Names

notch5
fa14b08
wu:fa14b08

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and signaling receptor activity. Involved in several processes, including animal organ development; blood vessel development; and neurogenesis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Is expressed in several structures, including digestive system; mesoderm; nervous system; pronephros; and vasculature. Orthologous to human NOTCH3 (notch receptor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

111 figures from 92 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 22 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With notch3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
CADASIL 1	Alliance	Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1	125310
infantile myofibromatosis	Alliance	?Myofibromatosis, infantile 2	615293
lateral meningocele syndrome	Alliance	Lateral meningocele syndrome	130720

Associated With notch3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000800	Notch domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR010660	Notch, NOD domain
Domain	IPR011656	Notch, NODP domain
Domain	IPR024600	Notch, C-terminal
Family	IPR008297	Notch
Family	IPR022331	Neurogenic locus Notch 3
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR035993	Notch-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR002110	Ankyrin repeat