UniProt ID: F1QEK2
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00117811}.
UniProt ID: A0A0R4IAI2
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00117811}.
UniProt ID: B8JJS4
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00117811}.
UniProt ID: F1QHP2
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00117811}.
UniProt ID: F1QKT4
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00117811}.
UniProt ID: F1R6E2
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00117811}.
UniProt ID: B8JJS3
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00117811}.
UniProt ID: F1Q6N9
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00117811}.
UniProt ID: Q90268
FUNCTION: Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. {ECO:0000269|PubMed:9671579}.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed during embryogenesis in the kidney, optic stalk, midbrain, otic vesicle and a row of cells along the spinal cord and the hindbrain.
DEVELOPMENTAL STAGE: First seen during the formation of neural keel. At 9-10 hours of development expression seen in two laterally located transverse stripes of cells in the rostral 1/3 of the embryo, and the two areas subsequently move towards the midline and form the posterior portion of the midbrain. Detected in the otic placode, Wolffian duct including the nephritic primordium and optic stalk at 10-12 hours. At 14-15 hours expression seen in the single cells along the spinal cord, presumably interneurons.
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