UniProt ID: P51029 |
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. TISSUE SPECIFICITY: Hindbrain r1, 2 and 5. PTM: Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity). {ECO:0000250|UniProtKB:P28026, ECO:0000250|UniProtKB:P56704}. PTM: Proteolytic processing by tiki1 and tiki2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of wnt8b. {ECO:0000250|UniProtKB:P28026}. SIMILARITY: Belongs to the Wnt family. {ECO:0000305}. |
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