UniProt ID: B0V1G8 |
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. {ECO:0000256|RuleBase:RU003500}. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}. SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683, ECO:0000256|RuleBase:RU003500}. |
UniProt ID: P43446 |
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for normal tooth development (PubMed:29178643). Regulates the expression of genes involved in tooth development (PubMed:29178643). {ECO:0000269|PubMed:29178643, ECO:0000305}. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9GZT5}. Secreted {ECO:0000250|UniProtKB:Q9GZT5}. DEVELOPMENTAL STAGE: Detected in embryos (at protein level) (PubMed:29178643). First detected during the segmentation period of embryogenesis (PubMed:8330668). Detected in the developing brain and spinal cord (PubMed:8330668). Detected at constant levels in embryonic head throughout embryonic development, from 18 hpf to 5 dpf (PubMed:29178643). Widely expressed in embryos at 56 hpf (PubMed:29178643). {ECO:0000269|PubMed:29178643, ECO:0000269|PubMed:8330668}. PTM: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. {ECO:0000250|UniProtKB:P27467, ECO:0000250|UniProtKB:P56704}. DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes arrest of tooth development. Otherwise, mutant embryos appear grossly normal, excepting some cartilage abnormalities. {ECO:0000269|PubMed:29178643}. MISCELLANEOUS: Wnt10a overexpression in embryos results in loss of anterior neural identity, causing a phenotype with small or no eyes. {ECO:0000269|PubMed:29178643}. SIMILARITY: Belongs to the Wnt family. {ECO:0000305}. |
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