UniProt ID: Q90275 |
FUNCTION: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (PubMed:12091300). Required for normal neural tube morphogenesis (PubMed:12091300, PubMed:21115806). Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain (PubMed:12091300). Functions with protocadherin pcdh19 to coordinate cell adhesion and cell movements during neurulation (PubMed:21115806). pcdh19 shows little cell adhesion activity on its own but exhibits robust homophilic cell adhesion when in a complex with cdh2 and appears to mediate the adhesion while cdh2 acts as a cell adhesion cofactor in the complex (PubMed:21115806, PubMed:22184198, PubMed:33004519). Contributes to neural progenitor cell patterning by promoting homophilic cell interactions (PubMed:33004519). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). {ECO:0000250|UniProtKB:P10288, ECO:0000250|UniProtKB:P15116, ECO:0000269|PubMed:12091300, ECO:0000269|PubMed:21115806, ECO:0000269|PubMed:22184198, ECO:0000269|PubMed:33004519}. SUBUNIT: Homodimer (via extracellular region) (By similarity). Can also form heterodimers with other cadherins (via extracellular region) (By similarity). Dimerization occurs in trans, i.e. with a cadherin chain from another cell (By similarity). Interacts with protocadherin pcdh19; the interaction confers robust cell adhesion activity on pcdh19 (PubMed:21115806, PubMed:22184198). {ECO:0000250|UniProtKB:P15116, ECO:0000269|PubMed:21115806, ECO:0000269|PubMed:22184198}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21115806}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15116}. Cell junction {ECO:0000250|UniProtKB:P19022}. Cell surface {ECO:0000250|UniProtKB:P15116}. Cell junction, desmosome {ECO:0000250|UniProtKB:P15116}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P15116}. TISSUE SPECIFICITY: Expression in the embryo is initially found in all deep cells but later becomes restricted to various epithelial and neuronal tissues. Found in discrete areas of cell-cell adhesion when epiboly is nearly completed. Expressed in adult brain, eyes and trunk. {ECO:0000269|PubMed:7873785}. DEVELOPMENTAL STAGE: Expression is first detected in the embryo during gastrulation. {ECO:0000269|PubMed:7873785}. DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1. {ECO:0000250|UniProtKB:P15116}. DISRUPTION PHENOTYPE: Morpholino knockdown results in aberrant early brain morphogenesis due to disrupted cell convergence in the lateral neural plate with mutants showing an abnormally wide neural plate (PubMed:21115806). Mutants show impaired directedness of cell movements and impaired coherence of movements among neighboring cells (PubMed:21115806). {ECO:0000269|PubMed:21115806}. |
UniProt ID: Q1L8K3 |
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. {ECO:0000256|RuleBase:RU004357}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU003318}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |