UniProt ID: Q90459 |
FUNCTION: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. {ECO:0000250|UniProtKB:P24385}. SUBUNIT: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex (By similarity). The cyclin subunit imparts substrate specificity to the complex (By similarity). {ECO:0000250|UniProtKB:P24385}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P24385}. Cytoplasm {ECO:0000250|UniProtKB:P24385}. PTM: Phosphorylation at Thr-282 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. {ECO:0000250|UniProtKB:P24385}. PTM: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation. The DCX(AMBRA1) complex represents the major regulator of CCND1 stability during the G1/S transition. {ECO:0000250|UniProtKB:P24385}. SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily. {ECO:0000305}. |
UniProt ID: A7YYE4 |
SIMILARITY: Belongs to the cyclin family. {ECO:0000256|RuleBase:RU000383}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |