UniProt ID: A2BGR3 |
FUNCTION: DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). {ECO:0000250|UniProtKB:Q2NKX8}. CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000250|UniProtKB:Q2NKX8}; SUBCELLULAR LOCATION: Chromosome, centromere {ECO:0000250|UniProtKB:Q2NKX8}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q2NKX8}. Chromosome {ECO:0000250|UniProtKB:Q2NKX8}. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. {ECO:0000250|UniProtKB:Q2NKX8}. SIMILARITY: Belongs to the SNF2/RAD54 helicase family. {ECO:0000305}. |
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