UniProt ID: Q3ZB95 |
FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. {ECO:0000256|ARBA:ARBA00002564}. CATALYTIC ACTIVITY: Reaction=D-mannose 6-phosphate = D-fructose 6-phosphate; Xref=Rhea:RHEA:12356, ChEBI:CHEBI:58735, ChEBI:CHEBI:61527; EC=5.3.1.8; Evidence={ECO:0000256|ARBA:ARBA00000757, ECO:0000256|RuleBase:RU000611}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|PIRSR:PIRSR001480-2, ECO:0000256|RuleBase:RU000611}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR001480-2, ECO:0000256|RuleBase:RU000611}; PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2. {ECO:0000256|ARBA:ARBA00004666, ECO:0000256|RuleBase:RU004248}. SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1 family. {ECO:0000256|ARBA:ARBA00010772, ECO:0000256|RuleBase:RU004189}. |
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