UniProt ID: Q5XJA0 |
FUNCTION: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity). Controls gastrulation movements and left/right (L/R) axis determination via smad3-mediated regulation of cdh1/e-cadherin. Regulates the formation of Kupffer's vesicle, a signaling center essential for establishing L/R asymmetry. Modulates smad3 activity through modulating nodal-acvr1/akt4 signaling. {ECO:0000250|UniProtKB:Q9JJX7, ECO:0000269|PubMed:18039968}. COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:23104058}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:Q9JJX7}; Note=Binds 1 magnesium or manganese ion per subunit. {ECO:0000269|PubMed:23104058}; SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95551}. Nucleus, PML body {ECO:0000250|UniProtKB:O95551}. TISSUE SPECIFICITY: Expressed ubiquitously during blastula stages and throughout gastrulation. Shortly after shield formation, expressed weakly in dorsal forerunner cells (DFCs). Between somite stages 5 and 9, expressed in the tailbud and around the Kupffer's vesicle at a higher level than the more uniform expression in the embryo. {ECO:0000269|PubMed:18039968}. DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. {ECO:0000269|PubMed:18039968}. SIMILARITY: Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH83404.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH97117.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH97117.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAK05007.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAK05424.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
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