UniProt ID: Q503M4

FUNCTION: Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution. {ECO:0000250|UniProtKB:Q6ZSM3}. CATALYTIC ACTIVITY: Reaction=creatine(in) = creatine(out); Xref=Rhea:RHEA:73043, ChEBI:CHEBI:57947; Evidence={ECO:0000250|UniProtKB:Q6ZSM3}; CATALYTIC ACTIVITY: Reaction=guanidinoacetate(in) = guanidinoacetate(out); Xref=Rhea:RHEA:73047, ChEBI:CHEBI:57742; Evidence={ECO:0000250|UniProtKB:Q6ZSM3}; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6ZSM3}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BGC3}; Multi-pass membrane protein {ECO:0000255}. SIMILARITY: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.

UniProt ID: F1Q846

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

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