UniProt ID: Q4VBK1 |
FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. {ECO:0000256|RuleBase:RU363115}. CATALYTIC ACTIVITY: Reaction=[protein]-C-terminal L-amino acid-glycyl- phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid- glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:67548, Rhea:RHEA-COMP:17323, Rhea:RHEA-COMP:17324, ChEBI:CHEBI:15377, ChEBI:CHEBI:64612, ChEBI:CHEBI:172940, ChEBI:CHEBI:172941; Evidence={ECO:0000256|ARBA:ARBA00029362}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67549; Evidence={ECO:0000256|ARBA:ARBA00029362}; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU363115}. SIMILARITY: Belongs to the peptidase C54 family. {ECO:0000256|ARBA:ARBA00010958, ECO:0000256|RuleBase:RU363115}. |
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