UniProt ID: A0A0R4IEA9 |
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000256|ARBA:ARBA00005043}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the ELP4 family. {ECO:0000256|ARBA:ARBA00007573}. |
UniProt ID: Q566Y1 |
FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. {ECO:0000250|UniProtKB:Q96EB1}. PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000250|UniProtKB:Q96EB1}. SUBUNIT: Component of the elongator complex. {ECO:0000250|UniProtKB:Q96EB1}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96EB1}. Nucleus {ECO:0000250|UniProtKB:Q96EB1}. SIMILARITY: Belongs to the ELP4 family. {ECO:0000305}. CAUTION: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification. {ECO:0000250|UniProtKB:Q96EB1}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |