UniProt ID: F1R8Z9 |
FUNCTION: Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. {ECO:0000269|PubMed:19011630, ECO:0000269|PubMed:19840756}. SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}. DEVELOPMENTAL STAGE: Strongly expressed in the shield, the floor plate in early somitogenesis, the posterior neural plate, the otic vesicles and later in the otoliths, the pronephric ducts, diencephalon, olfactory pits, briefly in the trigeminal ganglion, and in an anterior brain region that overlaps the pineal gland and later corresponds to the anterior tectal ventricle. {ECO:0000269|PubMed:18956329, ECO:0000269|PubMed:19011630}. DISRUPTION PHENOTYPE: Randomization of the left-right body. {ECO:0000269|PubMed:19284996}. SIMILARITY: Belongs to the FOXJ1 family. {ECO:0000305}. |
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