UniProt ID: C6KFA3 |
FUNCTION: G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:25118328). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:19745155). Also plays a role in inner ear development (PubMed:24067352). {ECO:0000250|UniProtKB:Q86SQ4, ECO:0000269|PubMed:19745155, ECO:0000269|PubMed:24067352, ECO:0000269|PubMed:25118328}. FUNCTION: [ADGRG6 N-terminal fragment]: Plays an important role in heart development (PubMed:24082093). Necessary and sufficient for axon sorting by Schwann cells independently of the ADGRG6-CTF (PubMed:25695270). {ECO:0000269|PubMed:24082093, ECO:0000269|PubMed:25695270}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25118328}; Multi-pass membrane protein {ECO:0000255}. TISSUE SPECIFICITY: Expressed in Schwann cells of the posterior lateral line nerve and in brain. {ECO:0000269|PubMed:19745155}. DEVELOPMENTAL STAGE: Detected from 30 hours post-fertilization to 4 days post-fertilization in Schwann cells of the posterior lateral line nerve. {ECO:0000269|PubMed:19745155}. DOMAIN: A short peptide sequence (termed the Stachel sequence) in the C-terminal part of the extra-cellular domain (ECD) functions as a tethered agonist. Upon structural changes within the ECD, e.g. due to extracellular ligand binding or mechanical movements, this intramolecular agonist is exposed to the 7TM domain, triggering G- protein activation. {ECO:0000269|PubMed:25533341}. DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results in defects in semicircular canal formation inner ear (PubMed:24067352). {ECO:0000269|PubMed:24067352, ECO:0000269|PubMed:24082093}. SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}. |
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