UniProt ID: F1RC64
CATALYTIC ACTIVITY: Reaction=ATP + glycine + L-gamma-glutamyl-L-cysteine = ADP + glutathione + H(+) + phosphate; Xref=Rhea:RHEA:13557, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:57925, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.3; Evidence={ECO:0000256|PIRNR:PIRNR001558};
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|PIRNR:PIRNR001558, ECO:0000256|PIRSR:PIRSR001558-2}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRNR:PIRNR001558, ECO:0000256|PIRSR:PIRSR001558-2};
PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. {ECO:0000256|PIRNR:PIRNR001558}.
SIMILARITY: Belongs to the eukaryotic GSH synthase family. {ECO:0000256|PIRNR:PIRNR001558}.
UniProt ID: A0A2R8QGJ2
CATALYTIC ACTIVITY: Reaction=ATP + glycine + L-gamma-glutamyl-L-cysteine = ADP + glutathione + H(+) + phosphate; Xref=Rhea:RHEA:13557, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:57925, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.3; Evidence={ECO:0000256|PIRNR:PIRNR001558};
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|PIRNR:PIRNR001558, ECO:0000256|PIRSR:PIRSR001558-2}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRNR:PIRNR001558, ECO:0000256|PIRSR:PIRSR001558-2};
PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. {ECO:0000256|PIRNR:PIRNR001558}.
SIMILARITY: Belongs to the eukaryotic GSH synthase family. {ECO:0000256|PIRNR:PIRNR001558}.
UniProt ID: Q5XJT8
CATALYTIC ACTIVITY: Reaction=ATP + glycine + L-gamma-glutamyl-L-cysteine = ADP + glutathione + H(+) + phosphate; Xref=Rhea:RHEA:13557, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:57925, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.3; Evidence={ECO:0000256|PIRNR:PIRNR001558};
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|PIRNR:PIRNR001558, ECO:0000256|PIRSR:PIRSR001558-2}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRNR:PIRNR001558, ECO:0000256|PIRSR:PIRSR001558-2};
PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. {ECO:0000256|PIRNR:PIRNR001558}.
SIMILARITY: Belongs to the eukaryotic GSH synthase family. {ECO:0000256|PIRNR:PIRNR001558}.
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