UniProt ID: Q6PHI9 |
FUNCTION: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). {ECO:0000250|UniProtKB:P20338, ECO:0000250|UniProtKB:P56371}. CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000250|UniProtKB:P20338}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000250|UniProtKB:P20338}; SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P20338}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20338}. Cytoplasm {ECO:0000250|UniProtKB:P20338}. Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. {ECO:0000250|UniProtKB:P20338}. SIMILARITY: Belongs to the small GTPase superfamily. Rab family. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH56535.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
UniProt ID: B0V0U3 |
FUNCTION: Protein transport. {ECO:0000256|RuleBase:RU367055}. CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000256|ARBA:ARBA00000249}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000256|ARBA:ARBA00000249}; SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367055}; Lipid-anchor {ECO:0000256|RuleBase:RU367055}; Cytoplasmic side {ECO:0000256|RuleBase:RU367055}. SIMILARITY: Belongs to the small GTPase superfamily. Rab family. {ECO:0000256|ARBA:ARBA00006270, ECO:0000256|RuleBase:RU367055}. |
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