UniProt ID: Q5RFW2 |
FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys- 63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q9NYJ8, ECO:0000269|PubMed:20493459}. SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9NYJ8}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol. {ECO:0000250|UniProtKB:Q9NYJ8}. DOMAIN: The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins. {ECO:0000250|UniProtKB:Q9NYJ8}. |
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