UniProt ID: A3QK15 |
FUNCTION: Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9D2R0, ECO:0000250|UniProtKB:Q9JMI1}. CATALYTIC ACTIVITY: Reaction=acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:16117, ChEBI:CHEBI:13705, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:456215; EC=6.2.1.16; Evidence={ECO:0000250|UniProtKB:Q9JMI1}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16118; Evidence={ECO:0000250|UniProtKB:Q9JMI1}; SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JMI1}. SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}. |
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