UniProt ID: Q803F6 |
FUNCTION: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. {ECO:0000255|HAMAP-Rule:MF_03016}. SUBUNIT: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with rps21. Interacts with several laminins including at least lamb1. Interacts with mdk. {ECO:0000255|HAMAP-Rule:MF_03016}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_03016}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03016}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. {ECO:0000255|HAMAP- Rule:MF_03016}. PTM: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. {ECO:0000255|HAMAP-Rule:MF_03016}. PTM: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. {ECO:0000255|HAMAP-Rule:MF_03016}. MISCELLANEOUS: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. SIMILARITY: Belongs to the universal ribosomal protein uS2 family. {ECO:0000255|HAMAP-Rule:MF_03016}. |
UniProt ID: B2GNT1 |
FUNCTION: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. {ECO:0000256|HAMAP-Rule:MF_03016}. SUBUNIT: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. {ECO:0000256|HAMAP-Rule:MF_03016}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_03016}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP- Rule:MF_03016}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. {ECO:0000256|HAMAP-Rule:MF_03016}. PTM: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. {ECO:0000256|HAMAP-Rule:MF_03016}. PTM: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. {ECO:0000256|HAMAP-Rule:MF_03016}. MISCELLANEOUS: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. {ECO:0000256|HAMAP-Rule:MF_03016}. SIMILARITY: Belongs to the universal ribosomal protein uS2 family. {ECO:0000256|ARBA:ARBA00006242, ECO:0000256|HAMAP-Rule:MF_03016, ECO:0000256|RuleBase:RU003631}. CAUTION: Lacks conserved residue(s) required for the propagation of feature annotation. {ECO:0000256|HAMAP-Rule:MF_03016}. |
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