UniProt ID: Q6NWD4 |
FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. {ECO:0000269|PubMed:15044455}. SUBUNIT: Component of the TIM23 complex at least composed of timm23, timm17 and timm50. {ECO:0000250|UniProtKB:Q3ZCQ8}. SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q3ZCQ8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q3ZCQ8}. DEVELOPMENTAL STAGE: At 48 hours post-fertilization (hpf), it is highly expressed in the CNS, particularly in the brain tissues. The pattern is the same at 72 hpf. {ECO:0000269|PubMed:15044455}. DISRUPTION PHENOTYPE: Massive apoptosis in the CNS, probably due to loss of mitochondrial function and increased cytochrome c release. {ECO:0000269|PubMed:15044455}. SIMILARITY: Belongs to the TIM50 family. {ECO:0000305}. |
UniProt ID: B2GQE9 |
FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. {ECO:0000256|RuleBase:RU365079}. SUBUNIT: Component of the TIM23 complex. {ECO:0000256|RuleBase:RU365079}. SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein {ECO:0000256|RuleBase:RU365079}. SIMILARITY: Belongs to the TIM50 family. {ECO:0000256|RuleBase:RU365079}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |