UniProt ID: Q7ZUC7 |
FUNCTION: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy- 5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity). {ECO:0000250|UniProtKB:Q9H7Z7, ECO:0000250|UniProtKB:Q9N0A4}. CATALYTIC ACTIVITY: Reaction=prostaglandin H2 = prostaglandin E2; Xref=Rhea:RHEA:12893, ChEBI:CHEBI:57405, ChEBI:CHEBI:606564; EC=5.3.99.3; Evidence={ECO:0000250|UniProtKB:Q66LN0}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12894; Evidence={ECO:0000250|UniProtKB:Q66LN0}; CATALYTIC ACTIVITY: Reaction=prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)- heptadecatrienoate + malonaldehyde; Xref=Rhea:RHEA:48644, ChEBI:CHEBI:57405, ChEBI:CHEBI:90694, ChEBI:CHEBI:566274; Evidence={ECO:0000250|UniProtKB:Q66LN0}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48645; Evidence={ECO:0000250|UniProtKB:Q66LN0}; ACTIVITY REGULATION: Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by glutathione (GSH) and 2-mercaptoethanol. {ECO:0000250|UniProtKB:Q66LN0}. PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000250|UniProtKB:Q66LN0}. SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q66LN0}. SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9H7Z7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9H7Z7}. SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}. |
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