UniProt ID: Q802F2 |
FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase activity. {ECO:0000250|UniProtKB:Q1H5H1}. CATALYTIC ACTIVITY: Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9; Evidence={ECO:0000250|UniProtKB:Q1H5H1}; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein {ECO:0000255}. TISSUE SPECIFICITY: Expressed in embryonic olfactory vesicles and the photoreceptor cell layer of the embryonic retina. Low level in embryonic epiphysis. {ECO:0000269|PubMed:12915322}. PTM: May contain a selenide-sulfide bond between Cys-44 and Sec-47. This bond is speculated to serve as redox-active pair (By similarity). {ECO:0000250}. SIMILARITY: Belongs to the SelWTH family. Selenoprotein T subfamily. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH54578.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAO65273.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABG54379.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
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