UniProt ID: A0JMQ0 |
FUNCTION: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}. SUBUNIT: Component of the PeBoW complex, composed of bop1, pes1 and wdr12. The complex is held together by bop1, which interacts with pes1 via its N-terminal domain and with wdr12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}. SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP- Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}. SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family. {ECO:0000255|HAMAP-Rule:MF_03027}. SEQUENCE CAUTION: Sequence=CAK04774.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
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