UniProt ID: Q8UW00 |
FUNCTION: Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Acts downstream of hnf1ba but is not required for induction of rhombomere r5/r6 gene expression in the hindbrain. {ECO:0000250|UniProtKB:P35680, ECO:0000269|PubMed:18945197}. SUBUNIT: Binds DNA as a dimer. Can form homodimer or heterodimer with HNF1-alpha (By similarity). {ECO:0000250|UniProtKB:P35680}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35680, ECO:0000255|PROSITE-ProRule:PRU00108}. TISSUE SPECIFICITY: First expressed at stage 10 in the intermediate mesoderm. Expressed in rhombomere r5 by 14 hpf with expression diminishing by 18 hpf. {ECO:0000269|PubMed:18945197}. SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000255}. CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator. {ECO:0000305}. |
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