UniProt ID: F1RDZ8 |
CATALYTIC ACTIVITY: Reaction=beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + H(+) + nicotinamide; Xref=Rhea:RHEA:16149, ChEBI:CHEBI:14649, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017; EC=2.4.2.12; Evidence={ECO:0000256|PIRNR:PIRNR005943}; PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D- ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00035007, ECO:0000256|PIRNR:PIRNR005943}. SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR005943}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR005943}. Cytoplasm {ECO:0000256|PIRNR:PIRNR005943}. Secreted {ECO:0000256|PIRNR:PIRNR005943}. SIMILARITY: Belongs to the NAPRTase family. {ECO:0000256|ARBA:ARBA00010897, ECO:0000256|PIRNR:PIRNR005943}. |
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