UniProt ID: Q5RHU2 |
FUNCTION: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin- dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. {ECO:0000256|PIRNR:PIRNR038143}. SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000256|PIRNR:PIRNR038143}. Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus {ECO:0000256|ARBA:ARBA00004105, ECO:0000256|PIRNR:PIRNR038143}. Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Membrane raft {ECO:0000256|PIRNR:PIRNR038143}. Cell projection, lamellipodium {ECO:0000256|PIRNR:PIRNR038143}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. SIMILARITY: Belongs to the podocalyxin family. {ECO:0000256|ARBA:ARBA00007029, ECO:0000256|PIRNR:PIRNR038143}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |