UniProt ID: Q6DGE9
FUNCTION: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development (PubMed:17189627, PubMed:17586488, PubMed:20440001, PubMed:20849610). Is necessary for normal early lens development (PubMed:24549050). {ECO:0000250|UniProtKB:Q8CGY6, ECO:0000269|PubMed:17189627, ECO:0000269|PubMed:17586488, ECO:0000269|PubMed:20440001, ECO:0000269|PubMed:20849610, ECO:0000269|PubMed:24549050}.
SUBUNIT: Interacts with apobec2a, apobec2b, hsp90a.1, hsp90a.2, hsp90ab1 and myosin. {ECO:0000269|PubMed:17586488, ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}.
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}.
TISSUE SPECIFICITY: Expressed in striated muscle tissue including somites, heart and craniofacial muscle. Detected in mesoderm adjacent to the dorsal midline during the late gastrula stages and in somitic mesoderm during development of trunk skeletal muscle. Also expressed in cranial skeletal muscle and in cardiac and smooth muscle. Detected in somitic muscle and heart primordium of 24 hour embryos. At later stages, expressed in muscles of pectoral fins, jaw, branchial arches and eye. {ECO:0000269|PubMed:12203738, ECO:0000269|PubMed:17189627}.
DEVELOPMENTAL STAGE: First detected at the late gastrula stages around 9 hours post-fertilization (hpf). Expression intensifies by the end of gastrulation around 10 hpf, continues into early somitogenesis stages around 12 hpf and persists in the somites until 96 hpf when the somites give rise to the trunk skeletal muscle. {ECO:0000269|PubMed:12203738, ECO:0000269|PubMed:17189627}.
SEQUENCE CAUTION: Sequence=AAH76400.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
This information was provided by UniProt through a collaboration with ZFIN. (1)