FUNCTION: Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. {ECO:0000269|PubMed:11802164, ECO:0000269|PubMed:11802165}. SUBUNIT: Interacts with fgfr1 and fgfr2. {ECO:0000269|PubMed:11802164}. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SEQUENCE CAUTION: Sequence=AAH94998.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; |